hospitals in us

Oncotarget published "Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation" which reported that To model this sequential genetic cooperativity, we coupled somatic lentivirus-mediated p53 knockdown in the adult right sciatic nerve with embryonic Schwann cell precursor Nf1 gene inactivation in two different Nf1 conditional knockout mouse strains. Using this approach, ~60% of mice with Periostin-Cre-mediated Nf1 gene inactivation developed tumors classified as low-grade MPNSTs following p53 knockdown. Similarly, ~70% of Nf1 /- mice with GFAP-Cre-mediated Nf1 gene inactivation developed low-grade MPNSTs following p53 knockdown. In addition, wild-type and Nf1 /- mice with GFAP-Cre-mediated Nf1 loss develop MPNSTs following somatic p53 knockout with different latencies, suggesting potential influences of Nf1 /- stromal cells in MPNST pathogenesis. Collectively, this new MPNST model system, presented in this Oncotarget study, permits the analysis of somatically-acquired events as well as tumor microenvironment signals that potentially cooperate with Nf1 loss in the development and progression of this deadly malignancy.

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hospitals in us

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Downregulation of T-Box 15 Gene Found as Prognostic Biomarker of HCC

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clinics in us

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