Онко-мишень: PRG3 индуцирует Ras-зависимую онкогенную кооперацию в глиомах

Oncotarget опубликовал статью « PRG3 индуцирует Ras-зависимую онкогенную кооперацию в глиомах », в которой сообщалось о связанном с нейронами гене PRG3, стимулирующем рост, выполняющем онкогенную кооперацию в глиомах. Исследователи определили нарушенные уровни PRG3 в злокачественных опухолях головного мозга человека, демонстрирующие либо повышенные, либо пониженные уровни PRG3 по сравнению с нетрансформированными образцами. Кроме того, несбалансированные уровни PRG3 в глиомах способствуют Ras-управляемой онкогенной амплификации с повышенной пролиферацией и миграцией клеток, хотя ангиогенез не затрагивается. Следовательно, PRG3 взаимодействует с RasGEF1, подвергается Ras-индуцированной нагрузке, тогда как делеция C-концевого домена PRG3 ингибирует Ras. Таким образом, данные автора Oncotarget показывают, что вмешательство в гомеостаз PRG3 усиливает онкогенные свойства и способствует потенциалу злокачественности в глиомах.

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