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When general population speak of modern medicine, precision plays one of the most important roles and human lives are directly dependent on it. Likewise, any researches pertaining to medicine are necessary to meet the top standards. The issue nowadays is that any outcomes of researches can be published online and used as a reference without being precisely verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and decided to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The key principle of this journal is related to Altmetric scores that are used as a quality indicator. That allows both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website provides a complete publications list with respective scores higher th...

Researchers identify genomic regions in DNA with hypermethylation, abundant MSRE sites, and low methylation levels that can be amplified and detected using MSRE-PCR analysis in diverse types of tumor DNA and normal tissue. DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity. DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity. A pair of U.S. researchers from Johns Hopkins University in Baltimore, Maryland, and from Genmab—an international biotech company in Princeton, New Jersey—collaborated in a study to demonstrate: “Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR.” This study was published as the cover paper of journal Volume 11, Issue #47 in Oncotarget. Methylation Errors Methylation is an important process in multiple functions in human DNA, including gene regulation and silencing through the rec...

When public mention contemporary medicine, accuracy plays one of the most significant roles and people’s lives are directly dependent on it. Hereby, any researches pertaining to medicine are required to meet the top standards. The challenge nowadays is that any recommendations of researches can be shared online and used as a reference without being properly verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and tried to generate an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The major principle of this journal is based on Altmetric scores that are used as a quality measure. That helps both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website has a complete publications list with corresponding scores higher than 100 a...

Researchers discuss their paper published in Oncotarget, entitled: “CD44+/EPCAM+ cells detect a subpopulation of ALDH high cells in human non-small cell lung cancer: A chance for targeting cancer stem cells?” hospitals in usa New-York hospital Los Angeles hospital Researchers explain their studies that were published in Oncotarget Researchers expand on their studies published in Oncotarget The Behind the Study series transcribes videos of chosen researchers elaborating on their recent papers published in Oncotarget. Visit the Oncotarget YouTube channel for more insights from outstanding authors. — I’m Dr. Beatrice Aramini. I’m an assistant professor in thoracic surgery from the University of Modena and Reggio Emilia, and a thoracic surgeon at University Hospital of Modena in Italy. I started to develop translational research project during my Ph.D. at the Alma Mater Studiorum University of Bologna in Italy, and during my research fellowship at the Department of Cardiothoracic Su...

When people speak of contemporary medicine, accuracy plays one of the most significant roles and people’s lives are directly dependent on it. Hereby, any researches pertaining to medicine are necessary to comply with the top standards. The problem nowadays is that any outcomes of researches can be posted online and used as a reference without being adequately verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this problem and attempted to come up with an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The main principle of this journal is based on Altmetric scores that are used as a quality indicator. That assists both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication. ” Oncotarget website provides a complete publications list with respective scores higher...

When general population discuss modern medicine, accuracy plays one of the most crucial roles and human lives are literally dependent on it. Hereby, any researches related to medicine are necessary to meet the top standards. The problem today is that any recommendations of researches can be published online and used as a reference without being thoroughly verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and attempted to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The major principle of this journal is based on Altmetric scores that are used as a quality indicator. That helps both readers and authors to quality-check publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website has a full publications list with respective scores higher than...

Oncotarget недавно опубликовал « Протеомика малых внеклеточных везикул, полученных из опухолей семейства сарком Юинга, выявляет потенциальные клинические биомаркеры », в которой сообщается, что помимо биопсии опухоли не существует клинически значимых биомаркеров ESFT. Кроме того, оценка опухолевой нагрузки при диагностике, мониторинг реакции заболевания на терапию и выявление рецидива заболевания ограничиваются рентгенографической визуализацией. Чтобы идентифицировать новые, клинически значимые биомаркеры, авторы оценили протеом субнабора небольших внеклеточных пузырьков, полученных из ESFT. Они выполнили первое высококачественное протеомное исследование sEV, полученных из ESFT, из 5 линий клеток ESFT, представляющих наиболее распространенные типы слияния EWS-ETS, и идентифицировали 619 белков, составляющих основной протеом sEV ESFT. Они сравнили эти основные белки с базами данных обычных белков плазмы и белков, связанных с sEV, обнаруженных в здоровой плазме, чтобы идентифицироват...

When general population discuss modern medicine, precision plays one of the most crucial roles and human lives are literally dependent on it. Hence, any researches pertaining to medicine are necessary to comply with the top standards. The challenge today is that any results of researches can be posted online and used as a reference without being adequately checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this problem and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The major principle of this journal is related to Altmetric scores that are used as a quality indicator. That assists both readers and authors to verify publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a complete publications list with respective scores high...

Oncotarget опубликовал статью « PRG3 индуцирует Ras-зависимую онкогенную кооперацию в глиомах », в которой сообщалось о связанном с нейронами гене PRG3, стимулирующем рост, выполняющем онкогенную кооперацию в глиомах. Исследователи определили нарушенные уровни PRG3 в злокачественных опухолях головного мозга человека, демонстрирующие либо повышенные, либо пониженные уровни PRG3 по сравнению с нетрансформированными образцами. Кроме того, несбалансированные уровни PRG3 в глиомах способствуют Ras-управляемой онкогенной амплификации с повышенной пролиферацией и миграцией клеток, хотя ангиогенез не затрагивается. Следовательно, PRG3 взаимодействует с RasGEF1, подвергается Ras-индуцированной нагрузке, тогда как делеция C-концевого домена PRG3 ингибирует Ras. Таким образом, данные автора Oncotarget показывают, что вмешательство в гомеостаз PRG3 усиливает онкогенные свойства и способствует потенциалу злокачественности в глиомах. hospitals in usa clinics in usa usa clinics lists usa hospi...

When general population speak of contemporary medicine, accuracy plays one of the most crucial roles and people’s lives are directly dependent on it. Hereby, any researches related to medicine are required to comply with the top standards. The problem today is that any outcomes of researches can be shared online and used as a reference without being properly verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this problem and tried to develop an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The main principle of this journal is based on Altmetric scores that are used as a quality indicator. That assists both readers and authors to verify publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website provides a full publications list with corresponding scores higher than 1...

When public discuss modern medicine, accuracy plays one of the most significant roles and human lives are directly dependent on it. Likewise, any researches pertaining to medicine are required to meet the highest standards. The challenge today is that any outcomes of researches can be shared online and used as a reference without being precisely verified and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and attempted to develop an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been established back in 2010. The major principle of this journal is based on Altmetric scores that are used as a quality measure. That assists both readers and authors to quality-check publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a complete publications list with respective scores above 100...

Oncotarget опубликовал статью « Пристрастие к Runx1 частично ослабляется потерей p53 в модели лимфомы Eμ-Myc », в которой сообщается, что гены Runx функционируют как доминантные онкогены, которые эффективно взаимодействуют с Myc или потерей p53, вызывая лимфому при сверхэкспрессии. Здесь они исследовали потребность в базальной активности Runx1 для поддержания опухоли в Eμ-Myc модели лимфомы Беркитта . В то время как нормальные лимфоидные клетки Runx1fl / fl допускают моноаллельную делецию, первичные лимфомы Eμ-Myc демонстрировали отбор по сохранению обоих аллелей, а попытки принудить делецию in vivo приводили к компенсаторной экспансии нулевых бластов p53, сохраняющих Runx1. Удивительно, но Runx1 может быть полностью вырезан из установленных клеточных линий лимфомы Eμ-Myc in vitro без очевидного воздействия на фенотип клеток. Анализ транскриптома клеток с делецией Runx1 выявил сигнатуру гена, связанную с лимфоидной пролиферацией, выживанием и дифференцировкой, и включал сильную дере...

When people speak of modern medicine, precision plays one of the most significant roles and people’s lives are directly dependent on it. Hence, any researches related to medicine are necessary to meet the highest standards. The challenge today is that any conclusions of researches can be shared online and used as a reference without being properly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality measure. That helps both readers and authors to quality-check publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website has a complete publications list with respective scores higher than 100...

Oncotarget published "Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation" which reported that To model this sequential genetic cooperativity, we coupled somatic lentivirus-mediated p53 knockdown in the adult right sciatic nerve with embryonic Schwann cell precursor Nf1 gene inactivation in two different Nf1 conditional knockout mouse strains. Using this approach, ~60% of mice with Periostin-Cre-mediated Nf1 gene inactivation developed tumors classified as low-grade MPNSTs following p53 knockdown. Similarly, ~70% of Nf1 /- mice with GFAP-Cre-mediated Nf1 gene inactivation developed low-grade MPNSTs following p53 knockdown. In addition, wild-type and Nf1 /- mice with GFAP-Cre-mediated Nf1 loss develop MPNSTs following somatic p53 knockout with different latencies, suggesting potential influences of Nf1 /- stromal cells in MPNST pathogenesis. ...

When public refer to modern medicine, accuracy plays one of the most crucial roles and human lives are literally dependent on it. Likewise, any researches pertaining to medicine are required to comply with the top standards. The issue nowadays is that any conclusions of researches can be published online and used as a reference without being thoroughly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this challenge and attempted to create an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That helps both readers and authors to verify publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication". Oncotarget website has a full publications list with corresponding scores above 100 as well as rep...